Various mutations in the p53 tumor suppressor can occur in cancer. These have different “fingerprints” and may serve as biomarkers for distinct tumors and targeted therapies. Genetic variations in the …

Sep 7, 2025 · People who are born with changes—called mutations—in the TP53 gene have a syndrome known as Li-Fraumeni syndrome and an increased risk for many different types of cancer.

Dec 19, 2025 · The TP53 gene is frequently mutated in many cancers. Learn about the function of this gene, how it plays a role in cancer, and approaches to treatment.

Mutations in TP53 can give rise to different isoforms, preventing their overall functionality in different cellular mechanisms and thereby extending the cancer phenotype from mild to severe.

Sep 18, 2025 · Explore TP53 mutation, its impact on cancer, detection methods, prognosis, and potential therapies targeting this key tumor suppressor gene.

Oct 30, 2025 · We review the methods used to assess for TP53 mutational allele status and provide recommendations, based on clinically available testing, for the accurate evaluation of TP53 gene …

TP53 gene mutations change single amino acids in p53, which impair the protein's function. Without functioning p53, cell proliferation is not regulated effectively and DNA damage can accumulate in cells.

Explore data for TP53 tumor variants identified in human tumor samples. Includes data on the type and position of variants, detailed information on the tumor in which the variants have been found, and on …

TP53 is the most commonly mutated gene in human cancers. These mutations are primarily non-synonymous changes that produce mutant p53 proteins characterized by loss of function, a dominant …

4 days ago · Mutant TP53 (mTP53) variants are diverse, and residual wild-type p53 function (functional, non-functional), gain-of-function (GOF) mTP53, and the number of mTP53 (single-hit, multi-hit) can …