Inhibition of ALAD by lead leads to anemia primarily because it both inhibits heme synthesis and shortens the lifespan of circulating red blood cells, but also by stimulating the excessive …

Nov 13, 2025 · Complete information for ALAD gene (Protein Coding), Aminolevulinate Dehydratase, including: function, proteins, disorders, pathways, orthologs, and expression.

Aminolevulinic acid dehydratase (ALAD) activity can be inhibited in situations including hereditary tyrosinemia type 1, lead intoxication, and exposure to styrene, trichloroethylene, or …

The ALAD gene provides instructions for making an enzyme known as delta-aminolevulinate dehydratase. Learn about this gene and related health conditions.

Jan 4, 2025 · The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of …

The ALAD gene encodes delta-aminolevulinate dehydratase, also known as porphobilinogen synthase (PBGS; EC 4.2.1.24), a cytosolic enzyme that catalyzes the second step in the …

Figure 9. Lead inhibition of ALAD leads to decreased oxygen in body tissues. The buildup of ALA itself is also harmful to the body.

May 8, 2024 · Explore the structure, function, and clinical implications of the ALAD gene, encoding the δ-aminolevulinic acid dehydratase enzyme critical for heme biosynthesis. Learn …

ALAD, or aminolevulinic acid dehydratase, is an enzyme that catalyzes the condensation of two ALA molecules to produce porphobilinogen and is involved in allosteric regulation, with …

Aminolevulinic acid dehydratase (ALAD) activity can be inhibited in situations including hereditary tyrosinemia type 1, lead intoxication, and exposure to styrene, trichloroethylene, or …