The data scientist’s goal is to simultaneously reduce bias and variance as much as possible in order to obtain as accurate model as is feasible. However, there is a tradeoff to be made when selecting ...

The Annals of Applied Statistics, Vol. 11, No. 4 (December 2017), pp. 2027-2051 (25 pages) Linear mixed models (LMMs) are among the most commonly used tools for genetic association studies. However, ...