Mutations are changes in the molecular "letters" that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including ...

A new long-read sequencing technique has helped researchers investigate how DNA mutations arise in a variety of contexts. A collaboration of researchers led by NYU Langone Health and NYU Grossman ...

Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of ...

Cancer genomes are the result of diverse mutation processes that have often accumulated over decades. Scientists from the German Cancer Research Center (DKFZ) and the Universities of Cambridge and ...

Arc Institute, a research organization that operates in collaboration with UC Berkeley, has released an artificial intelligence model that can classify and generate strands of DNA. This technology has ...

New study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

An international team of scientists has designed a new type of therapy to target the mutant toxic RNA that causes myotonic ...

From the time we are conceived and through old age, genetic mutations accumulate in all our tissues, eluding the body's typically efficient DNA repair machinery and potentially affecting our health ...

Proteins PIF1 and PCNA gather at sites of DNA damage in SETX-deficient cells, indicating activation of the BIR repair system. LA JOLLA, CA—The DNA inside our cells is constantly being damaged, and one ...