The complexity of signal transduction resulting from the contact of human immunodeficiency virus type 1 (HIV-1)-infected cells and mucosal cells has hampered our comprehension of HIV-1 mucosal entry.

Within the brain and other parts of the nervous system, synapses are key junctional points in between neurons (the nerve cells) where critical signals are transmitted. More specifically, the ...

Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous ...

Scientists provide promising new evidence that the 'planar cell polarity,' a powerful signaling pathway, is a widely used mechanism for the formation and maintenance of a large number of synapses.

A new signaling role is being proposed for the amyloid precursor protein. According to a September 20 paper in Translational Psychiatry, APP binds co-receptors of multiple branches of the Wingless/int ...

Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous ...

New research led by UC San Francisco scientists has revealed that mutations in a gene linked with brain development may dispose people to multiple forms of psychiatric disease by changing the way ...

The canonical Wnt signaling pathway participates in synapse function and stability, and previous research confirmed its impairment in Alzheimer's disease (AD).

Scientists believe one of the key culprits behind the cognitive decline seen in Alzheimer's are amyloid beta proteins that clump together and disrupt the brain's synaptic connections, but how they ...

Two roles of the actin cytoskeleton in T cell activation Figure 2: Model for actin dynamics in three stages of immunological synapse formation. Following antigen receptor triggering, it is clear that ...

Memories aren't made of actin filaments. But their assembly is crucial for long-term potentiation (LTP), an increase in synapse sensitivity that researchers think helps to lay down memories.