Neurofibromatosis type 2 is caused by a change in the NF2 gene located on chromosome 22. This gene encodes a protein known as merlin. Mutations in the NF2 gene disrupt the function of merlin, which is ...

Neurofibromatosis type 2 (NF2) is an autosomal‐dominant disorder characterised by the development of multiple tumours, most notably bilateral vestibular schwannomas. These benign tumours originate ...

Neurofibromatosis type 2 is most often diagnosed based on the presence of physical symptoms that are part of the specific diagnostic criteria for the disorder. Genetic testing for the NF2 mutation is ...

For patients with NF2-related schwannomatosis and progressive tumors, the ALK inhibitor brigatinib (Alunbrig) was associated with radiographic response for multiple tumor types, as well as ...

Neurofibromatosis type 1 (NF1) is a common genetic condition, affecting 1 in 3,000 individuals, and people with NF1 are at greater risk of developing a rare, aggressive form of cancer. Diagnosing ...