Geroscience examines the underlying biology of aging to delay chronic diseases and extend the healthy years of human life.

Cells in our bodies produce RNA based on genetic information stored in DNA, and RNA serves as a blueprint for making proteins ...

Aging is a systemic process that affects the entire body. Visible external signs of aging usually correspond to evidence of equivalent aging in the functioning of the internal organs. This indicates ...

Geneticist Anne Brunet explores what aging really is, how lifestyle choices might influence longevity, and the promising frontiers of aging research. Aging is a process that affects us all. But how ...

Cellular senescence, a state characterized by stable cell cycle arrest, has emerged as a critical process in maintaining tissue homeostasis by limiting the ...

Osaka, Japan – There are a multitude of products for sale that promise the appearance of eternal youth by erasing wrinkles or firming up jaw lines; but what if we could truly turn back time, at the ...

Aging and neurodegeneration are both known to disrupt the production of functional proteins in cells – a process called “proteostasis,” or protein homeostasis. Brain cells in particular fall prey to ...

Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years. Though ...

Within aging organisms, cells slowly lose their youthful precision: Membranes stiffen, repair systems malfunction, and proteins begin to misfold and pile up. One of the cell organelles that ...

Researchers create a massive single-cell atlas of the aging mouse brain, revealing how epigenetic changes and "jumping genes" drive neurodegeneration.