Hierarchical communication between cells with distinct positional memories orchestrates the regeneration of missing limb structures in axolotls.

Split hand/foot malformation (SHFM) is a congenital limb anomaly distinguished by the absence or malformation of the central digits in the hands and feet, often accompanied by syndactyly or ...

Atsuta and his colleagues confirmed that the fibroblasts were successfully reprogrammed into cells that can produce limb tissue. They detected three important proteins found in natural limb progenitor ...

In a collaborative study, researchers from Kyushu University and Harvard Medical School have identified proteins that can turn or "reprogram" fibroblasts - the most commonly found cells in skin and ...

(Morpolinos only knockdown genes transiently, so the team couldn't demonstrate the effects on later stages of development). But gene expression patterns in the region were also extensively disrupted, ...

-- Continued functional improvements wereobserved at 18 months in the low-dose cohort-- -- First look at functional outcomes in high-dose cohort found improvements 6 months after administration -- -- ...

Mapping limb regeneration is an intricate, molecular dance. If an axolotl loses a leg, it gets a new one–complete with a functional foot and all four toes. Over just a few weeks or months, bone, ...

EVRY, France--(BUSINESS WIRE)--Atamyo Therapeutics a clinical-stage biotechnology company focused on the development of new generation gene therapies targeting muscular dystrophies and ...

Globally, close to 60 million people are living with limb loss. Amputations can result from various medical conditions such as tumors, infections, and birth defects, or due to trauma from industrial ...