Anil Oza is a general assignment reporter at STAT focused on the NIH and health equity. You can reach him on Signal at aniloza.16. The hormone leptin was discovered 30 years ago to much fanfare.

Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with obesity, type 2 diabetes (T2DM), and metabolic ...

Leptin is an adipose tissue hormone that regulates energy and metabolic balance by activating the leptin receptor (LEPR). An imbalance in leptin or LEPR signalling — whether through hyperleptinemia or ...

Plasma leptin levels were linked with Alzheimer's disease PET pathology in cognitively unimpaired older adults in Korea. Lower baseline leptin was associated with a greater increase in tau over 2 ...

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss. Worldwide obesity rates have ...

Three decades ago, in a lab at The Rockefeller University, New York City, Jeffrey Friedman, MD, PhD, observed a paradox that would forever change our understanding of obesity. His subjects, a rare ...

Axons from AgRP neurons, in red, innervate oxytocin neurons, in green, in the PVH. Neuronal activity of AgRP neurons is required for normal targeting of their axons to oxytocin neurons, as well as for ...

A study more closely links obesity to dementia, finding that leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged ...

Those little fruit flies floating around the ripening cantaloupes pack some fat between their tiny wings. They’re cold-blooded and burn their fat to warm up. “They have really beautiful fat, the flies ...

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though a complex interplay of genes, diet, and environment contribute, 90% of ...