Wouldn’t it be ideal to observe how a medicine behaves in organs like the liver, intestines, and kidneys before testing it in living humans or animals? TNO’s new multi-organ perfusion model makes this ...
During drug development, researchers need to perform adequate nonclinical testing to ensure a drug’s safety and efficacy before starting clinical trials. An important aspect they must evaluate is a ...
PepT1 transports dietary and bacterial peptides in the gut. We hypothesized that cysteinyl-glycine would ameliorate the inflammatory effect of a bacterial peptide, ...
Cellular models of fetal and adult intestinal tissues generated by investigators from the Mucosal Immunology and Biology Research Center (MIBRC) at MassGeneral Hospital for Children (MGHfC) have ...
The rate of intestinal fluid loss was decreased significantly in eight patients with cholera when electrolyte solutions containing glucose were administered intragastrically or into the intestine for ...
Bowel ischemia is a potentially fatal medical condition caused by a decrease or obstruction of blood flow to the intestine. It is linked to many serious gastrointestinal disorders that can have ...
The role of intestinal epithelial cells (IECs) in the physiology of the gastrointestinal tract (GIT) of chickens and pathogenesis of various diseases in chickens is still poorly understood. IECs line ...
After the safety and efficacy of a biopharmaceutical, the efficiency of bioprocessing it might be the most crucial aspect. As Aleksandr Pogodaev, PhD—principal scientist in pharmacometrics, Novartis ...
Phase 1 trial of 17-AAG in patients with relapsed and refractory multiple myeloma (MM) No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2005 ASCO Annual ...
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