A subset of transcription factors classified as neural crest ‘specifiers’ are also core epithelial–mesenchymal transition regulatory factors, both in the neural crest and in tumour progression. The ...

A systematic map of pair-wise physical interactions among mammalian transcription factors will enable studies of transcriptional control in development and disease. The specification of cell and ...

The etiologic causes for non-Hodgkin lymphoma (NHL) remain largely unexplained. Challenges include the heterogeneous nature of NHL, the difficulty in accurately assessing exposures and the few genetic ...

Asingle human cell contains around 2,000 transcription factors, estimates Jason Li, president and CEO of Panomics in Redwood City, Calif. Their shifting alliances comprise a powerful layer of gene ...

DNA is commonly referred to as the instruction manual of the cell – a compendium of thousands of genes, the particular sequences of which determine the activities of the proteins they encode. But, in ...

Orthogonal arrays with clear two-factor interactions provide a class of designs that are robust to nonnegligible effects. If certain prior knowledge is available, then robust designs allow additional ...