“This is the first detailed study of how and where ORC regulates epigenetics and gene expression in human cells,” said Anindya Dutta, Ph.D., leader of the study and chair of the University of Alabama ...

The human genome has to be carefully organized so it will fit inside of the nuclei of cells, while also remaining accessible ...

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...

Picture CRISPR-Cas9, a gene editing technology, as a GPS-guided scalpel: gRNA directs the Cas9 enzyme, a protein that cuts ...

A new international study suggests that ancient viral DNA embedded in our genome, which were long dismissed as genetic "junk", may actually play powerful roles in regulating gene expression. Focusing ...

Epigenome editing has followed a similar path, in that more recent technological breakthroughs have enabled scientists to apply the discoveries made in previous decades. Epigenome editing performs a ...

There are hundreds of cell types in the human body, each with a specific role spelled out in their DNA. In theory, all it ...

Scientists identified 473 human genes that act as genetic “on/off switches,” shaping disease risk through tissue-specific or universal patterns regulated by DNA changes and hormones. Study: ...

The human genome is made up of 23 pairs of chromosomes, the biological blueprints that make humans … well, human. But it turns out that some of our DNA — about 8% — are the remnants of ancient viruses ...