The gonad arises as a bipotential organ primordium. Expression of the Y-linked gene, Sry, in the bipotential gonad leads to the differentiation of Sertoli cells, which orchestrate testis development.

Depiction of an early stage embryo. nobeastsofierce Science / Alamy Stock Photo In human embryos, testes in males and ovaries in females begin to develop at around four weeks, with sex determination ...

The precise positioning of organ progenitor cells constitutes an essential, yet poorly understood step during organogenesis. Using primordial germ cells that participate in gonad formation, we present ...

Early in mammalian embryonic development, long before the organism's ultimate form has taken shape, a precious subset of its cells are set aside for future use in creating offspring. This task bestows ...