Influential inventions often combine existing tools in new ways. The iPhone, for instance, amalgamated the telephone, web ...

Picture CRISPR-Cas9, a gene editing technology, as a GPS-guided scalpel: gRNA directs the Cas9 enzyme, a protein that cuts ...

Why do some tumors spread while others remain localized? The mechanisms governing the metastatic potential of tumor cells ...

Sherry Gao, Tyler Daniel (pictured) and their coauthors developed a new tool that can simultaneously and independently edit multiple genes and regulate their expression. Influential inventions often ...

CRISPR-Cas systems, originally a natural defense mechanism in bacteria, have become a groundbreaking tool for genetic engineering in medicine. These “gene scissors” can precisely edit specific ...

Changing an organism’s genome is a profound act, and the tools you use to make the changes don’t alleviate the need for responsible regulation. Unlike “traditional” genetically modified organisms (GMO ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

We know the genes, but not their functions—to resolve this long-standing bottleneck in microbial research, a joint research ...

Astellas Gene Therapies remains intent on treating X-linked Myotubular Myopathy (XLMTM) through a gene therapy—but instead of AAV-based resamirigene bilparvovec (AT132), Astellas is now partnering ...