The APOE4 variant may be more than just a genetic risk factor for Alzheimer's disease, new data from several cohorts suggested. Clinical, pathological, and biomarker changes indicated that APOE4 ...

What is the role of amyloid β deposits, amyloid oligomer formation, and tau proteinsin the development and progression of the disease, and what new advances have we learned in the last 3 to 5 years?

In a recent study published in JAMA Neurology a group of researchers determined the utility of a novel and commercially available immunoassay for plasma phosphorylated tau 217 (p-tau217) to detect ...

Crohn disease is characterized by periods of clinical remission alternating with periods of recurrence. Persistent inflammation can lead to complications that include strictures, fistulas, abscesses, ...

Thyroid storm pathophysiology explores the underlying causes and course of a rare thyroid condition. A thyroid storm is a potentially deadly condition, where thyroid hormones elevate rapidly. It can ...