Dysfunction of the complement system plays an important role in the pathogenesis of renal diseases. Complement inhibitors, such as C5 inhibitors, have shown efficacy in clinical trials, but may no be ...

Two targets, double success. This is the logic behind a new approach that uses monoclonal antibody (MAb) pairs to fight cancer. The two MAbs in the pair have different specificities and form ...

Characterizing the binding sites of monoclonal antibodies (mAbs) on target antigens, their epitopes, can aid in the discovery and development of new therapeutics, diagnostics, and vaccines. For ...

The complement system is an important part of the innate immunity. Complement activation products not only directly help to eliminate invading pathogens, but also participate in many immunological ...

Complement activation in patients with AAV who are in remission may be reflective of ongoing renal scarring. Persistent complement activation during disease remission in antineutrophil cytoplasmic ...

Credit: Shutterstock. Zilbrysq is a complement inhibitor. The Food and Drug Administration (FDA) has approved Zilbrysq ® (zilucoplan) for the treatment of generalized myasthenia gravis (gMG) in adult ...

Several types of antibody-mediated diseases are known. Some are thought to be adverse effects of vaccination, which is logical since vaccines, by definition, cause their effects via stimulation of the ...

PASC, which is otherwise known as long COVID, arises following the recovery from acute infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for ...