Neuroscience News

Study Reveals Ongoing Natural Selection in Modern Humans

A new study uses age-stratified allele frequencies to map ongoing natural selection and rare pathogenic variants.
Nanowerk

Allele frequency

Allele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a fraction or percentage. Specifically, it is the ...
Nature

Allele frequency, penetrance, and disease.

Genome-wide association studies (GWAS) are effective in detecting common alleles that contribute to the inherited component of common multifactorial diseases. Typically, the alleles identified by this ...
ascopubs.org

Variant allele frequency of circulating tumor DNA mutations detected in preoperative blood is indicator for lymph node metastasis in early stage lung cancer.

The genomic landscape of immune-related genes and its correlations with TMB and PD-L1 expression in Chinese NSCLC. This is an ASCO Meeting Abstract from the 2020 ASCO Annual Meeting I. This abstract ...
ascopubs.org

DNA Input, sequencing depth, and maximum somatic allele frequency may affect the concordance between blood TMB and tumor TMB.

Correlation of negative PD-L1 expression with TMB-H and MSI-H rates. Pulmonary F-18 FDG uptake of non-tumor area in lung cancer patients to provide risk stratification in postoperative acute ...