GPR30 in brain microvasculature responds to bicarbonate, and its deficiency protects against ischemia-reperfusion injury, reducing neurological deficits and blood-brain barrier disruption. These ...

Researchers have identified this receptor in brain mural cells that regulates reperfusion injury. Optimal pH homeostasis for cellular function is maintained by the acid-base balance through multiple ...

To define "steady-state" chronic hypercapnia in man, we studied 20 patients with stable carbon dioxide tensions from 34 to 103 mm of mercury and with no apparent complicating disorders. The whole-body ...

Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, ...